Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model

Recombinant human hyaluronidase-enabled subcutaneous pediatric rehydration.

OBJECTIVES The Increased Flow Utilizing Subcutaneously-Enabled (INFUSE)-Pediatric Rehydration Study was designed to assess efficacy, safety, and clinical utility of recombinant human hyaluronidase (rHuPH20)-facilitated subcutaneous rehydration in children 2 months to 10 years of age. METHODS Patients with mild/moderate dehydration requiring parenteral treatment in US emergency departments wer...

Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation.

Hyaluronidase (Hyal) and low m.w. hyaluronan (LMW HA) fragments have been widely reported to stimulate the innate immune response. However, most hyaluronidases used were purified from animal tissues (e.g., bovine testis Hyal [BTH]), and contain endotoxin and other unrelated proteins. We tested a highly purified recombinant human Hyal (rHuPH20) and endotoxin-free HA fragments from M(r) 5,000 to ...

Inflammation Recruitment in the Air Pouch Model of Lipopolysaccharide-Induced Neutrophil Response and Inhibits Does Not Stimulate an Acute Inflammatory Recombinant Human Hyaluronidase PH20

a comparison of teachers and supervisors, with respect to teacher efficacy and reflection

supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...

The Activity of Hyaluronan and Hyaluronidase PH20 in Inflammation-A Role by Reagent Contaminants?

Hyaluronan (or hyaluronic acid; HA), a component of the extracellular matrix (ECM), is composed of repeating polymeric disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine linked by a glucuronide bond. Hyaluronan is abundant in a variety of human tissues, including skin, umbilical cord, synovial fluid, cartilage, and skeletal tissues, and is turned over through the catabolic activity o...